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In fact, for every 500 g of oral B12 supplement ingested, only about 10 g is absorbed

L-Arginine is the only substrate in the biosynthesis of nitric oxide (NO), which plays critical roles in important physiological processes in the human body including neurotransmission (nerve communication between cells), vasorelaxation (dilation of blood vessels), protective cytotoxicity (removal or bad cells) and immunity

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This threshold has good diagnostic performance for B12 deficiency in patients with subnormal serum or plasma B12 concentrations and renal impairment (Supakul et al., 2020)