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Pritam P et al (2022) Antioxidants in Alzheimers disease: current therapeutic significance and future prospects

Evidence from clinical trials has validated riluzoles effectiveness in extending median survival of ALS patients by two to three months and slowing the decline in respiratory capabilities, a significant marker of ALS progression (25)

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XW, YH, FC, MW, and YX performed the experiments and acquired the data

Mutations in the DLG motif disrupt the low-affinity binding of Keap1 with Nrf2, resulting in the stabilization of Nrf2, although the association between Keap1 and Nrf2 through the high-affinity binding site, ETGE, is retained
