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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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Molecular Metabolism , 49

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MRI results showed mainly reversible brain atrophy with delayed myelin formation, although some patients had normal MRI findings [94,95,96]

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Regular follow-up appointments, including blood tests, can track nutrient levels and detect potential adverse effects

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