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According to the FPI model, a human TBI can occur without a skull fracture and can lead to edema, gray matter injury, and hemorrhage [227]

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Additionally, protein and transcriptomic analyses of cocultured neurons and astrocytes demonstrated that synaptic activation of neurons promotes changes in the transcriptional program of astrocytes and leads to the upregulation of astrocytic glycolysis via the CREB pathway (Mamczur et al

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