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The generated ROS can trigger the Mitogen-activated protein kinase signaling route (MAPK), thereby activating p38 MAPK, ERK, and JNK, leading to glomerulosclerosis, renal interstitial fibrosis, damage caused by oxidative stress, pancreatic -cell apoptosis, inflammatory responses, and increased collagen synthesis in cells
Apidologie 41, 99108
57 852859 10.1016/j.jhep.2012.05.024 [DOI] [PMC free article] [PubMed] [Google Scholar] Morohaku K., Pelton S
doi: 10.1016/0003-2697(90)90546-l
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It also showed beneficial impacts on glycemic and blood pressure control as well as lipid metabolism in hypertensive patients without serious adverse effects such as liver and kidney dysfunction [181]
