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Functional studies indicate that glutathione peroxidase activity saturates at 7090 g/L serum selenium, further explaining why supplementation beyond this threshold may not enhance antioxidant capacity ( 5.4 Practical considerations In selenium-replete populations, large trials (e.g., SELECT) found no reduction in cardiovascular events with 200 g/day of selenomethionine and even observed a potential rise in type 2 diabetes incidence (Zhang et al., 2017)

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Thus, further comprehensive research involving diverse populations and varied methodological approaches is essential to validate and enhance the accuracy of our findings