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Description
Since many pathologic and toxic conditions result in sustained increase in cytosolic free Ca 2+ , which can lead to activation of CMK and phosphorylation of GCLC, theoretically, inhibition of GCL may further contribute to toxicity under these conditions
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However, when iron was added to AP incubations, we did not observe any boost in AP activity (Figure 2)
Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression
Wu and Chu, 2021)
