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and protect against toxicity from cisplatin

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Given that polyamine synthesis is dependent upon methionine, MR may be a novel approach to inhibit cancer cell growth by downregulating polyamine formation

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Decreased levels of GSH have been noted in alcoholics, smokers, and patients with chronic liver disease [13]

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Of note, in vitro measurements of miRNA 3 end accessibility to nucleases indicate that miRNAs typically require 1819 nt to be stably bound by the PAZ domain of human AGO2 and AGO3, depending on the primary sequence of the 3-terminal nucleotides 56

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