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Aging is a network phenomenon: dozens of pathways decline simultaneously, they interact with each other, and intervening in one without accounting for the others produces incomplete, sometimes counterproductive results

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doi: 10.7150/ijbs.57078

These findings are associated with a reduced gene expression of osteoprotegerin, sclerostin, calcitonin receptor (CTR), insulin-like growth factor binding protein 5 and RUNX2