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The most robust HDL signaling activation is mediated by bioactive lipids on HDL, namely the lysosphingolipid sphingosine-1-phosphate (S1P)

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The gut microbiome influences brain function and inflammation, potentially affecting mental health

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Plantar hyperpigmentation (also known as plantar melanosis [increased melanin], volar pigmented macules, benign racial melanosis, acral pigmentation, acral ethnic melanosis, or mottled hyperpigmentation of the plantar surface) is a benign finding in many individuals and is especially prevalent in those with darker skin tones