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Description
In phase 3 trials, after 56 weeks of treatment, 62% of patients receiving contrave 32 (bupropion SR 360 mg/naltrexone SR 32 mg) lost at least 5% of their body weight as compared to 23% of patients in the placebo group [240]

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Fresh tendon tears, recent muscle strains, and post-surgical recovery situations often warrant standard or even aggressive dosing protocols

There were separate hemorrhagic zones and/or foci of necrosis, with the largest diameters in controls
