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The mechanism suggests it should work regardless of menopausal status

From mitochondria to atherosclerosis: the inflammation path

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Liu X, Chen A, Liang Q, Yang X, Dong Q, Fu M, Wang S, Li Y, Ye Y, Lan Z, Chen Y (2021) Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway

Additionally, it facilitates drought stress resistance by modulating stomatal aperture improves shelf life and storage quality of crop plants (Mekonnen et al