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In addition, the sphingolipid pathway is involved in the regulation of leukemia cell apoptosis, thus targeting sphingolipid metabolism also has considerable clinical significance (141)

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Our results suggest that, as organisms age, the circadian system shifts greater regulatory priority to the mitigation of accumulating cellular stress

From the results of Wei et al, every mmol/liter of increase in total cholesterol was associated with 1.32 times the risk of ED (95% confidence interval 1.04-1.68), while every mmol/liter of increase in high density lipoprotein cholesterol was associated with 0.38 times the risk (95% confidence interval 0.18-0.80) [122]

[DOI] [PMC free article] [PubMed] [Google Scholar] Lee A.H., Scapa E.F., Cohen D.E., Glimcher L.H