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[16] [17] Whereas the latter directly act on the dopamine transporter (DAT) to inhibit the reuptake and/or induce the release of dopamine, bromantane instead acts via indirect genomic mechanisms to produce a rapid, pronounced, and long-lasting upregulation in a variety of brain regions of the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) (also known as DOPA decarboxylase), key enzymes in the dopamine biosynthesis pathway

For in vitro cell culture analysis the composition was prepared in sterile DMEM HG medium and did not contain preservatives

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In homologous desensitization, only agonist-activated receptors are desensitized while in heterologous desensitization, both agonist-activated and non-activated receptors sharing the same signaling pathways are inactivated