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Reportedly, serum and urine levels of citrulline, ornithine, threonine, and methionine were found decrease substantially following both single (10 mg/kg, i.p.) and escalating (10, 12.5, 15, 20, and 30 mg/kg, i.p.) administration of MA, returning to baseline levels after a 2-day withdrawal period in Sprague Dawley rats 49

Thiele, I

These altered functions caused by TMX may be due to the identified oxidative damage, and they are most likely linked to neuronal dysfunction, as previously suggested by Farag et al

doi: 10.1016/0005-2760(91)90089-Z