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Chronic nitrous oxide B-12 poisoning (usually from use of nitrous oxide as a recreational drug), however, may result in B-12 functional deficiency even with normal measured blood levels of B-12 [45] Phenytoin (Dilantin), phenobarbital, primidone (Mysoline): These anticonvulsants have been associated with reduced vitamin B-12 absorption, and reduced serum and cerebrospinal fluid levels in some patients

J Bacteriol 175:55955603

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