hif-2α glutathione HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1: Cell Reports Shown to reduce cellular protein levels of HIF HIF1α and HIF2α: sibling rivalry
Description
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When intracellular iron accumulation and the redox system become imbalanced, excessive production of lipid peroxides will occur, ultimately inducing ferroptosis

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By targeting key signaling pathways such as IL-6/STAT3, autophagy, glycolysis, and Wnt/ -catenin, as well as by modulating the tumor microenvironment, ginsenosides enhance the efficacy of chemotherapy drugs in cancer types that exhibit resistance, including breast, lung, pancreatic cancers, and glioblastoma
