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Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)

Irisin also significantly alleviates tubular epithelial cell injury and fibrosis by inhibiting Smad3 phosphorylation and suppressing the expression of Nox4 (a downstream regulator of ferroptosis) in the UUO mouse model, thus blocking Smad3-mediated ferroptosis (202)

Int J Mol Sci 2018;19:690

Then appropriate amount of glutathione reductase was added into the cuvette

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