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19,84 Hepatocyte-specific SIRT1 knockout mice display liver steatosis, triglyceride accumulation, and increased de novo lipogenesis, even under standard dietary conditions, accompanied by SREBP-1c activation and impaired PGC-1/peroxisome proliferator-activated receptor alpha (PPAR) signaling

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Each of these studies individually reported an association between the Leu variant and coronary heart disease, with a final number of 1,560 CAD patients and 978 controls, resulting in a significant OR, 1.61 (95% CI, 1.252.07) [90]