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185 The increased expression of Wnt5a not only activates the Wnt/PCP pathway, but also upregulates DKK1which has an antagonistic effect on canonical Wnt signalingjointly mediating the occurrence of apoptosis and aggravating cerebral I/R injury

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AMD is a heterogenic and multi-factorial disease that can also be influenced by numerous environmental and genetic risk factors [3,4,7], which significantly contribute to the development of the disease