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Extensive evidence has confirmed that specific ferroptosis-related metabolic signals or byproducts were involved in the function, viability, and differentiation of multiple T-cell subgroups, impacting their reactivity to inflammation, infection and tumor immunity ( As was reported recently in tumor immunity, the ferroptotic interaction between CD8+ T cell-secreted IFN- and tumor cells is known to induce the elicitation of tumor ferroptosis and reinforcement of anti-tumor activity ( Besides, regulatory T (Treg) cells with a deletion of PDK1 have been implicated in the generation of excessive ROS, which consequently leads to amplified ferroptosis of themselves (53)

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

Importantly, genetic variation is a modifier of glutathione status and influences response to nutritional factors that impact glutathione levels

doi: 10.1038/s41598-017-06484-6 225 QuanC.LiC.MaH.LiY.ZhangH

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