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Thus pre-treatment with L-arginine counteracted the antidepressant-like effect of imipramine, venlafaxine and bupropion (Krass et al., 2011), while inhibition of nitric oxide levels within the hippocampus can induce antidepressant like effects (Joca and Guimaracs, 2006)

Its high specificity is a key area of research interest, as it has been shown in preclinical models to induce a strong GH pulse without significantly impacting other hormones such as cortisol, prolactin, or aldosterone, and without the appetite-stimulating effects associated with ghrelin itself

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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Won C.H.J., Li K.K., Guilleminault C
