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Historically, pulse oximeters have been developed, tested, and calibrated largely on patients with lighter skin tones

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Third generation sequencing is performed through single-molecule real-time (SMRT) sequencing provided by PacBio, which is able to analyze the kinetics of polymerase [49], fulfilling an impactful role in genetic disorder diagnosis, especially for repetitive sequences-associated diseases, where short-read sequencing is not able to provide correct diagnoses through technical limitations (the length of the reads could not be sufficient for mapping repetitive regions longer than the respective read) [52]

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