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If the cellular clearance rate of misfolded SOD1 is inadequate, increasingly frequent hydrophobic interactions ultimately give way to aggregation, forming larger amorphous structures that stress the cellular machinery 21

of tauopathies is defined as intracellular accumulation of neurofibrillary tangles (NFTs) consisting of aggregated hyper- and abnormal phosphorylation of tau protein and neuroinflammation

KDIGO AKI Guideline Work Group

Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model

In 2009, a number of studies showed that the GPx-4 overexpression strongly protected the retina from oxidative damage-induced retinal degeneration (83)