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Histopathological changes were evaluated by Hematoxylin and Eosin (H&E) and Alcian blue-periodic acid-Schiff (AB-PAS)

To overcome these problems, researchers have developed various novel drug delivery systems in recent years, including pH-responsive colon-targeted granules, protein-based nanoparticles, and targeted-responsive liposomes, to improve the stability and targeted delivery of natural products in vivo (Pujara et al., 2021)

plantarum) and Akkermansia muciniphila (A

not approved for routine medical use

Major sources include: Foods Rich in Vitamin B12 Vitamin B12 is naturally found primarily in animal-based foods, such as: Beef liver and pork liver (the most concentrated sources) Red meat, poultry, and fish Eggs, especially egg yolks Shellfish such as clams and oysters Fatty fish like salmon, tuna, and sardines Dairy products including cows milk, yogurt, and cheese For individuals who follow a vegetarian diet, Vitamin B12-fortified foods can be a helpful choice, such as fortified cereals or fortified soy milk