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Confirming the findings from previous trials, the tirzepatide weight-lowering efficacy was still impressive yet blunted in patients with T2D, as shown in the SURMOUNT 2 trial

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MECHANISM CATEGORIES SAFETY Side effects GI: nausea, vomiting (titration-dependent) Injection-site reactions Hypoglycemia risk when combined with insulin Known interactions Insulin additive hypoglycemia risk Contraindications History of MTC or MEN2 (theoretical class effect) REGULATORY STATUS FDA Not yet FDA-approved as of 2026-05

However, tissue-level effects including elevated collagen synthesis, altered cytokine expression, and increased angiogenesis signaling persist for 4872 hours

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