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doi: 10.1017/S0007114516001999

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Since the mid-1980s and 1990s, the role of amino acids in the development of fatigue has been discussed [3,6,7,8,9], and evidence demonstrated that plasma glutamine concentrations and the glutamine/glutamate plasma ratio are reduced in athletes under chronic fatigue and overtraining syndrome, raising a question about the possible ergogenic effects of glutamine supplementation [10,11,12,13]

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