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The polyunsaturated nature of PUFAs enables critical signaling and membrane fluidity functions while conferring peroxidation susceptibility, rendering membranes rich in PUFA-phospholipids-synthesized by ACSL4 and LPCAT3-vulnerable to ferroptosis through iron-catalyzed Fenton reaction-mediated oxidation (116)

* Correspondence: Jiangjiang Pu, [email protected]

147 FSHR is a G protein-coupled receptor (GPCR) and fluoride alters the conformation of G protein, 149 which regulates the level of secondary messengers (cAMP and Ca 2+ )

Under homeostatic physiological conditions, activated microglia and astrocytes can produce ROS and nitric oxide (NO) molecules that play roles in defense mechanisms against microbial pathogens

This phenomenon is known as substrate channeling , or more broadly, metabolic channeling