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TNF- and IFN- regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells

Hewitt EW

Interferons can also drive ZBP1-dependent necroptosis and PANoptosis (112, 113), and regulate cell fate through p53-dependent induction of Growth Arrest and DNA Damage-Inducible Protein 45 (Gadd45g) and Dual-Specificity Phosphatase 5 (Dusp5), which modulate cell cycle and promote apoptosis (114, 115), thus coupling viral clearance with epithelial repair dynamics (116)

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

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