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For cases that we can catch earlier we need to Attempt to provide glucose precursors by mouth: Many small doses of propylene glycol (10 mls) given every 2 hrs over the course of the day is preferable to one or two doses of no more than 30 ml per treatment

Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem

Based on an in-home use test of Blink Triple Care, March 2025

Consistency: Ensures every vial and dose is measured to the same standard

Given that NNMT has been reported to be a primary metabolic enzyme[36] and a major clearance pathway for intracellular NA,[15] it is likely that these small molecules are directly and selectively inhibiting the conversion of NA to 1-MNA