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PRRT with octreotide aims to selectively irradiate somatostatin receptor 2 (SSTR2)-expressing neuroendocrine tumor cells and the surrounding blood vessels to inhibit the angiogenetic response during treatment 67

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Real-world complexity in preclinical studies A significant limitation of most preclinical studies lies in the genetic diversity clinical researchers face when treating a human population

doi: 10.1038/nm1025

Other studies have revealed compositional and functional changes in gut microbiota (dysbiosis) and subclinical intestinal inflammation as possible drivers of TJ destabilization and leaky gut in animal models of arthritis and humans with RA [2, 3]