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When it becomes oxidized, it can break down yielding a large variety of compounds including a, -unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carboncarbon double bond or by Schiff base formation at the carbonoxygen double bond (Esterbauer et al., 1991

Nitric oxide (NO) and GSH levels were determined spectrophotometrically using the method reported by Montgomery and Dymock (1961)Montgomery (1971), with reagent kits purchased from Biodiagnostic Company (Egypt)

The results showed that the nanoemulsions improve the water-solubility of the drug, which is more easily absorbed by the gastrointestinal tract and enhances the pharmacokinetics of the orally administered drug