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Our previous study (Li et al., 2017) revealed higher expression levels of NNMT in the toe extensor muscle, typically reliant on anaerobic energy metabolism for power generation, compared to the soleus muscle, typically reliant on aerobic energy metabolism

Low vitamin B12 can cause fatigue, weakness, memory problems, tingling in the hands and feet, and pale skin

Many pharmacy clinics now offer consultations for vitamin B12 injections

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This proposed synergy and the specific doses here are not clinically validated , and neither compound has approved human use