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First, the recognition that the gut microbiome is an essential determinant of neural, immune, and endocrine homeostasis: It is interesting to note that reasonably influential reviews of the ENS from 10 years ago that recognized the interactions between the cellular elements of the ENS in the control of intestinal homeostasis did not mention the gut microbiome (29, 136, 267, 329)

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An additional confirmation of those was the low level of the collagen-specific amino acid, hydroxyproline, in the samples treated with anti-MMP-9 antibodies, compared to the control ones (Goffin et al., 2016)