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Mechanistically, CNIs inhibit calcineurin, preventing the dephosphorylation and nuclear translocation of NFATa critical step in cytokine transcription

VEGF upregulation, nitric oxide synthesis, collagen deposition

32 , 50 , 52 , 55 MM cells in the BM niche can also simultaneously express enzymes of the canonical or noncanonical ADO pathway, either on the surface of cells or on extracellular vesicles

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