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Separating evidence from enthusiasm is exactly the approach the orthopedic community needs right now

Although the complete molecular mechanism underlying changes in GCL expression during chronic cholestasis or in response to UDCA has not yet been clarified, Yang and colleagues showed a transient and early increase in GSH-related enzymes, followed by their dramatic decrease in a second phase of cholestasis

Aging skin is fragile, prone to tears, and often exposed to chronic injuries that lead to pressure sores, diabetic ulcers, and other damages

Although it is not well known whether loss of intestinal barrier per se in IBD patients is causal to bone loss in these patients (see chapter on IBD and bone for further details), our lab has shown that intestinal inflammation without weight loss in an IBD model can lead to significant bone loss suggesting a link [85]