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Macrophages can be categorized into three main types: the unactivated M0 type, the classically activated pro-inflammatory M1 type, and the alternatively activated anti-inflammatory M2 type (Zhao and Zhao, 2019

Mol Cell Biochem, 121: 37-43

As MMPs depend on zinc for their activation, zinc exerts precise control over inflammatory responses by inhibiting MMP-1-mediated lymphocyte infiltration and preventing MMP-9-induced basement membrane disruption (22, 23)

Targeting glutamine metabolism may provide therapeutic avenues for treating PDAC [60], and glutamine mimicry inhibits tumour progression through asparagine metabolism [61]