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Cells vary in size and shape and are vacuolated

Emerging therapeutic opportunities for integrin inhibitors

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KEAP1 has highly reactive thiol groups that act as a sensor for the NRF2 inducers.4 The cysteine residue (Cys151) in the KEAP1-BTB domain is essential for NRF2 activation,5 while Cys288 and Cys297 are crucial for the suppression of NRF2 activity.6 The Kelch domain of KEAP1 mediates the binding of the Neh2 domain to NRF2 and thereby negatively regulates NRF2 transactivation
