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A significant limitation of nasal drops is their imprecision in dosing when compared to other delivery devices, making them less suitable for medications that require strict dose accuracy (Tandel et al., 2011

Bok M, Zhao ZJ, Jeon S, Jeong JH, Lim E (2020) Ultrasonically and iontophoretically enhanced drug-delivery system based on dissolving microneedle patches

Furthermore, if the aim is to improve stability and drug-like properties, the acyl-hydrazone bond can be converted to an amide bond 129

Liu S., Wen Y., Shan X., et al., ChargeAssisted Stabilization of Lipid Nanoparticles Enables Inhaled mRNA Delivery for Mucosal Vaccination, Nature Communications 15 (2024): 9471