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Description
Clear epithelioid cell forms help to differentiate the lesion from a desmoplastic melanoma or sclerosing blue nevus
World J Pediatr

Changing your method will take some adjustment

While freckles themselves are benign, their presence indicates sun exposure, which is a risk factor for skin cancer

That there exist interspecies differences in biosynthetic pathways mediated by gut microbiota metabolism between mice and humans is consistent with numerous other examples of how gut microbiomes of mammalian species can differ (44)
