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[DOI] [PubMed] [Google Scholar] 195.Dypbukt JM, Ankarcrona M, Burkitt M, Sjoholm A, Strom K, Orrenius S, Nicotera P

WHAT SIDE EFFECTS ARE POSSIBLE
Because of the way glutathione is metabolized and transported, excessive amounts can interfere with how your body retains zinc
Using gene knockouts together with transcriptomic and metabolomic profiling, we identified an important shift in redox balance due to GR deficiency, which disrupted energy metabolism and weakened the oxidative stress defense, culminating in a notable decline in virulence

Further studies showed that nutlin-3 increases the P53 level in wild-type U-2OS, ACHN, Caki-1 and A549 cells, which could resist ferroptosis induced by erastin-2
