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Additionally, calcitonin is a 32 amino acid hormone secreted by the C-cells of the thyroid gland in response to elevated levels of calcium in the serum and gastrointestinal hormone gastrin

Cancers 11, 597

Abbreviations MBC: Metastatic breast cancer PC: Pancreatic cancer NSCLC: Non-small cell lung cancer OC: Ovarian cancer T-AML: Therapy-related acute myeloid leukemia AML-MRC: AML with myelodysplasia-related changes siRNA: Small interfering RNA aTTP: Acquired thrombotic thrombocytopenic purpura mRNA: Messenger RNA NPs: Nanoparticles PLA: Polylactic acid PGA: Polyglycolic acid NK: Natural killer BNPs: Biomimetic nanoparticles EPR: Enhanced permeability and retention NDs: Nanodiscs HDLs: High-density lipoproteins SR-B1: Scavenger Receptor Class B Type 1 FARs: Folate receptors LDL: Low-density lipoprotein FI: Fluorescence imaging MRI: Magnetic resonance imaging CT: Computed tomography PET: Positron emission tomography PEG-LIP: Pegylated liposomes RGD: Arg-Gly-Asp NIR: Near-infrared MNPs: Magnetic nanoparticles ROS: Reactive oxygen species CCM-NPs: Cancer cell membrane-coated nanoparticles ICG: Indocyanine green FL/PA: Fluorescence/photoacoustic EMT: Epithelial-to-Mesenchymal Transition WFA: Withaferin-A AuNPs: Gold nanoparticles ABCG2: ATP-binding cassette subfamily G member 2 DNC: Dendritic nanoparticles PD-L1: Programmed cell death ligand 1 DTX: Docetaxel BCM: Borate cross-linked micelle PTX: Paclitaxel NCM: Non-cross-linked micelles HPMAm: Hydroxypropyl methacrylamide HSP90: Heat shock protein 90 RES: Reticuloendothelial system ACT: Adoptive cell therapy MAB: Monoclonal antibody PFS: Progression-free survival OS: Overall survival ICIs: Immune checkpoint inhibitors PD-1: Programmed cell death protein 1 HL: Hodgkin lymphoma CTLA-4: Cytotoxic T-lymphocyte-associated protein 4 CRC: Colorectal cancer PROTACs: Protein hydrolysis-targeting chimeras POI: Protein of interest PSRNs: PH/cathepsin B sequentially responsive nanoparticles CDK4/6: Cyclin-dependent kinases 4 and 6 CRC: Colorectal cancer ICBs: Immune checkpoint blockades CAR-T: Chimeric antigen receptor T cell immunotherapy CARs: Chimeric antigen receptors NGs: Nanogels TCR: T-cell receptor EGFR: Epidermal growth factor receptor PSMA: Prostate-specific membrane antigen HER2: Human epidermal growth factor receptor 2 ADCs: Antibodydrug conjugates Tmab: Trastuzumab APCs: Antigen-presenting cells DC: Dendritic cell PD-L1: Anti-PD-L1 antibody CTLs: Cytotoxic T lymphocytes LNPs: Lipid nanoparticles TME: Tumor microenvironment TRK: Tropomyosin receptor kinase TAMs: Tumor-associated macrophages OMVs: Outer membrane vesicles mRNA: Messenger RNA PBA: Phenylboronic acid SA: Sialic acid DOX: Doxorubicin MEs: Milk-derived exosomes PDT: Photodynamic Therapy PTT: Photothermal Therapy AuNRs: Gold nanorods PLK1: Polo-like kinase-1 MDR: Multidrug resistance ABC: ATP-binding cassette COPD: Chronic obstructive pulmonary disease CVD: Cardiovascular diseases MI: Myocardial infarction CT-PET: Computed tomography-positron emission tomography USPIO: Ultra-small superparamagnetic iron oxide TMV: Tobacco mosaic virus TAP: Thrombin-activated fluorescent peptides SPIONs: Superparamagnetic iron oxide nanoparticles AS: Atherosclerosis VSMCs: Vascular smooth muscle cells TF: Tissue factor HA: Hyaluronic acid SIM: Simvastatin PDA: Polydopamine uPA: Urokinase plasminogen activator Fu: Fucoidan AMI: Acute myocardial infarction -LA: -Lipoic acid NGR1: Notoginsenoside R1 RAGE: Receptor for advanced glycation endproducts I/R: Ischemia/reperfusion MSN: Mesoporous silica nanoparticles Dex: Dexamethasone PAH: Pulmonary arterial hypertension ACE: Angiotensin-converting enzyme PASMCs: Pulmonary artery smooth muscle cells MDA: Malondialdehyde GSH: Glutathione SOD: Superoxide dismutase GI: Gastrointestinal MN: Microneedle GLP-1: Glucagon-like peptide-1 DPP4: Dipeptidyl peptidase-4 TRL: Tacrolimus AD: Atopic dermatitis MTX: Methotrexate DED: Dry eye disease RGCs: Retinal ganglion cells GO: Graphene oxide MRT: Mean residence time AUC: Area under the curve References Jeevanandam J, Chan YS, Danquah MK

Side Effect Comparison Both agents share gastrointestinal side effects as their primary tolerability issue

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