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Additionally, these treatments reversed the expression of key metabolic genes: downregulated genes such as Pgc1a and Glut2 , and upregulated genes like G6pc, Pck1, Sglt1, Dgat2, Fasn , and Scd , restoring them to levels comparable to those in lean mice (143)

The first-night effect of sleep occurs over nonconsecutive nights in unfamiliar and familiar environments

In states of obesity and aging, NNMT is often overexpressed, leading to the excessive methylation and excretion of nicotinamide

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