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Rodent-model studies describe protocol-defined endpoints typically across one to four weeks

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100 Consistent with this, paracellular flux of [ 3 H]mannitol (hydrodynamic radius of 3.6 ), but not [ 14 C]inulin (hydrodynamic radius of 11.5 ), was also increased, indicating that a decrease in TER resulted from tight junction-dependent permeability, not epithelial damage

For pigmentation concerns, 36 months may be needed