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Changes in the Incidence of Infantile Spinal Muscular Atrophy in Shikoku, Japan between 2011 and 2020

Interestingly, mitochondrial dysfunction has been demonstrated in animal models induced by exogenous toxicants such as the propionic acid adult rodent model (39, 40) and the prenatal valproic acid exposure rodent model (41), as well as in genetic animal models of ASD, including the Rett syndrome (28), phosphatase and tensin homolog gene haploinsufficiency (42), and Angelman syndrome (43) rodent models of ASD

In particular, our 2012 controlled study demonstrated the superiority of treatment results when adding vitamin E (600 mg/daily = group A) to a combination therapy (verapamil injection and iontophoresis + blueberries oral + propolis oral + topical Diclofenac/for 6 months = group B): (group A versus group B) success in reducing plaque size 97.14% versus 68.57% ( p = 0.004)

[DOI] [PubMed] [Google Scholar] Phulara SC, Pandey S, Jha A, Chauhan PS, Gupta P, Shukla V

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