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Under physiological conditions, the Neh2 structural domain of Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm, facilitating Nrf2 ubiquitination and subsequent degradation ( 3.1.3 TRPM4 channels and endothelial dysfunction in atherosclerosis Ye et al

Am J Human Genet 105(3):534548 Chen TR et al (1973) Assignment of the genes for malate oxidoreductase decarboxylating to chromosome 6 and peptidase B and lactate dehydrogenase B to chromosome 12 in man

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The sensitivity of R 4 parameters ( k p4 ) with respect to model OCR output is in good accordance with the AIC/BIC analysis, confirming the need for the R 4 reaction, which is present in both the triad and the comproportionation models, but not in the reduced model