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Nat Genet 25:302305
If you are not deficient, a B12 injection does not add measurable energy or speed up weight loss

In order to minimise the amount of SAM that is lost in this process, methylcobalamin is today obtained directly in supplements

doi: 10.1227/NEU.0b013e3182350893

Therefore, the partial success of these drugs can be identified by examining the effects of these drugs on autophagy