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In RA mouse models, histopathological scoring indicated a significant reduction in joint inflammation and synovial hyperplasia in the HRPS NPs group, which was further confirmed by Micro-CT and MRI imaging techniques

The phytocannabinoids THC and Cannabidiol (CBD) have been also reported to exert anti-tumour effects on U-87 MG cell-derived tumour xenografts by decreasing cancer growth via cell apoptosis (Torres et al., 2011)

This absence of mGluR-mediated buffering could make aspartate a particularly potent excitotoxin, underscoring the need for further investigation

The degradation process involves hydroxylation and destabilization of HIF1 by -KG-dependent prolyl hydroxylases (PHDs) or asparaginyl hydroxylases such as factor inhibiting HIF-1 (FIH-1) 125

Moderate doses within recommended dietary allowances are generally safe, but excessive supplementation is unnecessary