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In response to cold sensors in the skin, a neural signal is sent to the hypothalamus, which then sends a signal to smooth muscle tissue surrounding blood vessels causing them to constrict and reduce blood flow

10.1254/jphs.95.19 46 LozicM.StambolijaV.KrezicI.DugandzicA.Zivanovic-PosilovicG.GojkovicS.et al (2020)

Epithalon, primarily known for its telomere-lengthening effects, also increases neurogenesis rates and accelerates neuron differentiation

Therefore, they are very helpful for treating painful orthopedic conditions