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Cancer cells may exhibit survival mechanisms to counter high MG levels, such as increased Glo1 expression and activity

Gclc w/f or Gclc w/w mice (Gclc WT) and Gclc f/f mice (hereafter referred to as Gclc L-KO) were monitored following tail-vein injection with AAV-TBG-Cre (Fig

The lack of function of the enzymes of glutathione production in these conditions suggests that more efficient resolution of the effects of glutathione depletion may require the administration of the complete molecule as demonstrated in vitro in the HIV + macrophage study [52]

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After 3 h the cells were harvested by centrifugation for 15 min at 7000 g